The following effects can occur in the treatment area during and after a treatment. These are caused by exposure to cold temperatures. These side effects occur because cryolipolysis affects the treatment area in a similar manner to frostbite. These effects are temporary and generally resolve within days or weeks.

During a treatment

• Sensations of pulling, tugging, and mild pinching at the treatment site.

• Intense cold, tingling, stinging, aching, cramping. These sensations subside as the area becomes numb.

Immediately after a treatment

• Redness and firmness.

• Transient blanching and/or mild bruising around the edges of the treatment area.

• Tingling and stinging.

One to two weeks after a treatment

• Temporary redness, swelling, bruising, and skin sensitivity at the treatment site.

• Tenderness, cramping, and aching.

• Itching, skin sensitivity, tingling, and numbness. Numbness can persist up to several weeks after a treatment.

There are other side effects that can occur specific to the chin area

• Sensation of fullness in the back of the throat after submental area treatment.

• Cold exposure to the hypoglossal nerve may cause tongue deviation following treatment of the submental area.

• Cold exposure to the marginal mandibular nerve may cause lower lip weakness following treatment of the submental area.

• Cold exposure to the submandibular gland may cause dry mouth, or decrease in saliva production, following treatment of the submental area.

There are some rare side effects that have been seen both in clinical studies and commercial use

• Paradoxical hyperplasia: Visibly enlarged firmer tissue volume within the treatment area, which may develop two to five months after treatment, possibly even after a visible result is noticed. It is a very rare but serious side effect of cryolipolysis that occurs most in men. Surgical intervention for correction may be required.

• Late-onset pain: A typical onset several days after a treatment and resolution within several weeks.